The global demand for Implantable Drug Delivery solutions is rising fast, and at Demax we believe every success story begins with a single, robust conduit – the polyamide (PA) tube. As both a manufacturer and an innovation partner, we have spent decades refining this unassuming component. Today, our durable PA tubes stand at the center of life-saving devices, ensuring therapies reach the body with accuracy, gentleness, and absolute reliability. Why Durable PA Tubes Define Implantable Drug Delivery Success A modern implant can only perform as well as the channel that feeds it. PA tubes – often called Single-Lumen Tubes – bridge the gap between formulation and physiology. They guide drugs, contrast agents, or surgical tools through delicate anatomy without compromising patient safety. Demax engineers source medical-grade polyamide for three critical reasons: biocompatibility, mechanical strength, and chemical resistance. Polyamide resists abrasion and kinking, yet remains flexible enough to follow complex vascular paths. In our clean-room lines the resin is extruded, annealed, and laser-inspected in one continuous loop, giving every meter of tubing a profile that exceeds ISO 10993 and USP Class VI. •  Key Performance Benefits ✅Minimal wall variation safeguards flow precision ✅High burst pressure protects against accidental rupture ✅Smooth inner lumen reduces drag on drug payloads ✅Low-friction surface enables easy catheter tracking Bullet points tell only half the story. In practice, clinicians notice how quickly a Demax PA tube primes, how smoothly a guidewire rides its lumen, and – most important – how confidently they can advance an implantable pump without worrying about split lines or micro-leaks. These hands-on advantages translate directly into shorter procedure times and lower complication rates, both major contributors to the real-world success of Implantable Drug Delivery therapies. Demax Engineering At Demax, we believe excellence in implantable medical devices begins with precision – and that starts at the tubing level. Our PA tube production is not simply a manufacturing process, but a complete engineering ecosystem. It combines design, simulation, prototyping, testing, and ongoing clinical feedback into a seamless loop of continuous improvement. Each batch of tubing begins as a digital model. We use advanced finite-element analysis to simulate how our tubes will perform under real-world stresses – pulsatile pressure from implanted pumps, extreme flexing during catheterization, and prolonged exposure to bodily fluids. These simulations help us refine every aspect of the tube’s geometry before a single gram of resin is extruded. Once the physical production begins, every tube undergoes rigorous quality control. Automated dimensional scanners measure outer diameter and wall thickness with micron-level precision. Our tolerance window is tight: •Outer diameter range: 0.5 – 10.0 mm •Outer diameter tolerance: ±0.02 mm •Minimum wall thickness: 0.03 mm •Wall thickness tolerance: ±0.02 mm These specifications may appear ordinary, but in practice, they define the performance envelope for highly demanding applications. Our PA tubes are essential components in a wide range of devices, including microcatheters for neurovascular interventions, PTA balloon catheters for peripheral artery treatments, angiography catheters, and braided catheter shafts. In many cases, the PA material is used in both the inner and outer layers, combining

Minimally Invasive Interventional Delivery Systems are reshaping modern medicine, offering patients quicker recovery, smaller scars, and better outcomes. At Demax, we have perfected these technologies so clinicians can work with confidence and precision. The following article outlines how our microcatheter platform fuels smarter healing, why clinical teams trust us, and where we see the field heading next. Precision at the Core Our microcatheters sit at the heart of today’s Minimally Invasive Interventional Delivery Systems. Each device begins with an ultra-smooth PTFE inner layer. This helps embolic agents and contrast media glide without resistance, protecting fragile vessels from trauma. Surrounding that liner is a braided shaft engineered for trackability, pushability, and steerability. The result is a catheter that slips through the most tortuous anatomy yet responds instantly to a surgeon’s hand. •  Built for Seamless Navigation The outer diameter ranges from 0.5 mm to 3.0 mm, striking the ideal balance between flexibility and structural integrity. Combined with variable lengths, physicians can tailor the device to fit cerebral, coronary, or peripheral vasculature. Pre-shaped tips – straight, 45°, 90°, or tapered – further simplify vessel engagement. Radiopaque markers translate every subtle movement onto live fluoroscopy, cutting procedure time and radiation dose. ✅  Key Features at a Glance •Hydrophilic coating enables silky advancement through lesions •Four tip shapes offer precise alignment with diverse vessel angles •Multiple French sizes (2.0F – 2.8F) meet assorted flow and embolic volume needs •Biocompatible polyurethane or nylon shells reduce inflammation risks •Rigorous in-house fatigue testing guarantees durability for extended cases Because every microcatheter leaves our ISO-certified facility fully inspected, interventionalists can focus on treating the patient rather than questioning the tool. Clinical Impact and Growing Indications By combining smart device design with operator skill, Minimally Invasive Interventional Delivery Systems now cover a broad spectrum of interventions. Demax microcatheters in particular are driving progress across five high-value therapeutic areas. •  Targeted Vascular Therapy Angiography and angioplasty remain cornerstone techniques for mapping and reopening stenotic vessels. Our slim shafts navigate distal branches without guide-wire exchanges, lowering the risk of dissection and spasm. In many centers, this has pushed procedural success rates above while trimming OR time. •  Embolization & Oncology Synergy Blocking abnormal blood flow demands pinpoint accuracy. The braided construction of our microcatheter allows clinicians to lodge embolic coils or liquid agents exactly where they want – no more, no less. Tumor devascularization, AVM closure, and uterine fibroid treatment all benefit from this precision, slashing repeat-procedure rates and accelerating symptom relief. ✅  Expanding Indications •Thrombectomy: Rapid removal of cerebral or peripheral clots to prevent stroke sequelae •Localized drug delivery: Direct infusion of chemotherapeutics, antibiotics, or gene vectors into hard-to-reach lesions •Intravascular diagnostics: Seamless passage for IVUS, FFR, and OCT catheters to refine treatment strategy •Stent and balloon placement: Stable platform for device deployment, even in calcified or tortuous segments Clinical teams report smoother workflows because one microcatheter can handle mapping, therapy, and verification – all through the same vascular access. •  Advancing Patient Outcomes Shorter procedures mean less anesthesia, fewer contrast loads, and lower hospital bills.

A Structural Heart Delivery System must slide, bend, and reposition inside vessels that can be tortuous, calcified, or highly delicate. At Demax, we believe the single most decisive factor in achieving this smooth, predictable motion is the quality of the hydrophilic coating applied to every guidewire, catheter introducer, and delivery shaft that exits our cleanrooms. In the following analysis we explain why the coating matters, how we engineer it, and where the technology is headed – all from an original-equipment-manufacturer’s viewpoint. Advancing Patient Outcomes with Hydrophilic Coatings Modern transcatheter valve repair and replacement procedures depend on perfect control. When a cardiologist advances a guidewire through the aortic arch or manipulates a delivery catheter across the mitral valve, any hesitation can increase fluoroscopy time, create endothelial trauma, or even trigger embolic events. Hydrophilic coatings mitigate these risks by binding to water molecules the instant they contact blood or saline, forming a micro-thin hydration layer that lowers the coefficient of friction by up to 80 % compared with uncoated stainless-steel shafts. •  Material Science Behind the Coating Inside every Demax guidewire lies a dual-core structure. Stainless-steel segments deliver pushability proximal to the operator’s hand, while nitinol offers super-elastic flexibility at the distal region. Over this metallic backbone we apply a covalently bonded PTFE-based polymer matrix only 3 – 5 µm thick. The chemistry may sound esoteric, but the clinical benefits are practical: •  The hydration layer conforms instantly to vessel curvature, minimizing shear stress. •  Surface energy remains low even after repeated repositioning, reducing platelet activation. The coating’s microscopic “lock & key” anchoring technique prevents flaking, so lubricity lasts for procedures that can exceed two hours. Crucially, the polymer chosen is radio-transparent, so it never interferes with the marker bands that show the operator where the tip is. Demax Engineering Excellence in Structural Heart Delivery Systems From raw-material receipt to final pouch sealing, every Demax Structural Heart Delivery System moves through a vertically integrated quality chain. We machine, coat, and laser-weld under a single roof, enabling real-time feedback loops between R&D, production engineering, and in-process quality control. ✅  Zero-flaw hydrophilic coating line  • Fully automated dip & cure cycles with humidity control < 35 % RH  • Inline optical inspection at 20 µm resolution to detect pinholes or drips ✅  Balanced mechanical profile  • Proximal 304 SS for push; distal nitinol for kink resistance  • Laser-cut taper transition removes abrupt stiffness changes ✅  Radiopaque confidence  • Platinum-iridium tip coils and markers visible under low-dose fluoroscopy  • Optional distal J-tip for atraumatic entry ✅  Clinical versatility  • Diameters from 0.014” to 0.038” and lengths up to 300 cm  • Straight, angled, and shapable tips to accommodate aortic, mitral, or tricuspid approaches Our coating line is ISO 13485 and cGMP compliant, backed by biocompatibility data according to ISO 10993-5, -10, and -11. Each production lot undergoes extractables/leachables screening and a simulated-use friction test in heparinized porcine blood. Only batches that pass a 10 % coefficient-of-variation threshold move forward to EtO sterilization. •  Quality Control & Compliance Regulatory dossiers can stall

In the evolving field of minimally invasive surgery and interventional medicine, Braided Catheter Shaft design plays a crucial role in enhancing navigation precision and procedural success. As a trusted manufacturer committed to advancing catheter technology, Demax has developed a high-performance Braid & Coil Reinforcement Tube that significantly improves flexibility, torque control, and overall handling performance. With our proprietary materials and customizable construction, our braided catheter shafts help medical professionals perform with greater confidence and safety. At Demax we build every Braided Catheter Shaft with a single goal in mind: give physicians fingertip-level command inside the most delicate vessels. By weaving high-grade SUS304 or nickel-titanium filaments between medical-grade polymers, we transform raw materials into a responsive extension of the operator’s hand – a shaft that steers accurately, resists kinking, and keeps critical devices on course. Engineering the Demax Braided Catheter Shaft for Superior Precision Our engineering philosophy is simple: precision begins long before the catheter reaches the cath-lab. It starts on the braiding line where wire tension, pick-per-inch (PPI) density, and spindle count interact to create a perfectly balanced tube. •  Material Layering We laminate three synergistic layers: ✅Outer Jacket (TPU / Pebax / PA) – delivers a low-friction, abrasion-resistant surface while accepting hydrophilic coatings. ✅Braid or Coil Reinforcement (SUS304, Nitinol, or stainless steel) – round or flat wire, 8- to 72-spindle patterns (1×1, 1×2, 2×2) give controllable torque profiles. ✅Inner Liner (PTFE / TPU / Pebax / PA) – ultra-smooth lumen maintains flow and device compatibility even at 5 – 15 mm inner diameters. This composite keeps wall thickness within 0.07 – 0.3 mm while holding ±0.0125 mm ID and ±0.1 mm OD tolerances – tight enough to eliminate guesswork during navigation. Beyond dimensions, our braid angle and coil pitch are tuned to balance two opposing forces: pushability and trackability. A shallower angle strengthens axial stiffness for long lesion crossings; a steeper angle enhances torsion for whip-like tip rotation. With computer-controlled machines we lock those parameters into every meter of shaft, ensuring reproducibility from batch to batch. But numbers alone do not convey the tactile difference. Surgeons often describe the Demax shaft as “alive” – subtle wrist motions transmit instantly to the tip while the body stays resilient against crush and bend. That lively feedback reduces overcorrection, tightens catheter loops, and ultimately raises procedural confidence. Clinical Advantages When the guidewire must snake through a 2 mm cerebral branch or an iliac tortuosity, millimetric error is unacceptable. The Demax Braided Catheter Shaft turns design theory into bedside efficiency by delivering three concrete benefits: ✅Higher First-Pass Success – Consistent torque response lets physicians steer into ostia without repeated repositioning, shortening fluoroscopy time. ✅Lower Force, Less Trauma – A flexible distal zone paired with strong proximal support allows gentle advancement, reducing endothelial injury risk. ✅Stable Device Delivery – Stent systems, micro-coils, or embolic agents track smoothly through the PTFE liner, minimizing friction spikes that can jolt tip position. We see these gains daily across specialties: •Vascular Interventions: Guiding and distal access catheters maintain coaxial alignment during complex bifurcations, aiding rapid stent deployment. •Endoscopy & Urology: Braided

At Demax we continually refine the science of intervention. Our latest advancement, the Coil Reinforced Catheter, combines the tensile strength of precision-braided alloys with the gentle touch of next-generation polymers. In this article we share the engineering logic, the clinical impact, and the partnership opportunities that help physicians deliver safer, faster, and more predictable care. Engineering Strength with Surgical Sensitivity A catheter must steer through tortuous anatomy, withstand repeated torque, and still protect delicate tissue. The Coil Reinforced Catheter solves this challenge by marrying a three-layer design with micro-engineered reinforcement. 1) Tri-Layer Construction •Outer Layer – TPU, Pebax, or PA provides a low-friction, kink-resistant skin that slides smoothly through introducers and valves. •Middle Layer – SUS304 stainless steel, nickel-titanium, or flat-wire braid delivers radial strength while a helical spring core absorbs sudden bends. •Inner Layer – PTFE or Pebax ensures a glassy lumen for seamless fluid flow and device delivery. 2) Key Performance Benefits ✅High torque transmission for precise tip placement ✅Consistent pushability that resists buckling in long lesions ✅Proven anti-explosion rating for sudden pressure spikes ✅>30 % reduction in bending fatigue versus non-reinforced tubes Because every procedure is different, Demax offers custom weaving densities (8 – 72 spindles) and patterns (1 x 1, 1 x 2, 2 x 2). Inner diameters range from 0.5 mm to 15 mm with tolerances as tight as ±0.0125 mm, while wall thickness can be tuned from 0.07 mm for neuro work to 3 mm for large-bore access. 3) Why Materials Matter Nickel-titanium memory wire adds gentle elasticity. Flat stainless wire maintains a low profile without sacrificing hoop strength. By combining these alloys inside a Pebax jacket we create a catheter that flexes where you need it to – and nowhere else. Clinicians feel less “whip,” gain accurate haptic feedback, and navigate complex vessels in fewer fluoroscopy shots. That translates into shorter procedure times and reduced radiation for everyone in the room. Real-World Clinical Benefits Across Specialties Strong engineering means little without tangible outcomes. Since its launch, the Coil Reinforced Catheter has shown measurable gains in angiography, neuro-intervention, and minimally invasive surgery. •  Vascular Interventions Interventional cardiologists demand fast contrast injection, tight curve control, and zero compromise during stent delivery. The catheter’s high burst resistance allows full 8 bar injections without ballooning, while its smooth PTFE lumen keeps pressure gradients low. Operators report a clearer angiographic roadmap and sharper device response during balloon inflation. •  Neurovascular Access Navigating cranial vessels tests every millimeter of a catheter. Our braid-spring hybrid maintains column strength through the carotid siphon and seats microcatheters with confidence. Fewer exchanges mean lower embolic risk, and the lubricious inner wall preserves coating integrity on fragile neuro coils. •  Endoscopy and Urology ✅Stable suction during gastroscopy even when sharply flexed ✅Reliable irrigation in ureteroscopy without lumen collapse ✅Smooth passage through tight scopes thanks to thin-wall Pebax In a multicenter study, clinicians recorded a decline in overall procedure time and a drop in accessory exchanges when switching from a standard polymer catheter to the Demax Coil Reinforced Catheter. •  Wider Applications at a Glance Angiography Catheter –

The medical tubing industry has experienced steady growth in recent years, and extrusion technology remains at the core of this development. Medical extrusion tubing is used in a wide range of applications, from intravenous lines to catheters and drug delivery systems. As healthcare needs evolve and technology advances, the extrusion medical tubing market continues to shift, shaped by innovation, regulation, and global demand. One of the key trends driving the market is the growing use of minimally invasive surgical procedures. These procedures often require specialized tubing that can navigate the human body with precision and safety. Extruded tubing is ideal for this purpose due to its flexibility, thin walls, and ability to carry fluids or devices. As hospitals and surgical centers increasingly favor less invasive techniques, the demand for high-performance medical tubing grows in parallel. Another notable shift is the increasing adoption of advanced materials. While traditional materials like PVC and silicone remain widely used, newer options such as thermoplastic elastomers (TPE), polyether ether ketone (PEEK), and fluoropolymers are gaining popularity. These materials offer improved chemical resistance, biocompatibility, and durability, making them more suitable for long-term or demanding medical uses. Manufacturers are investing in material science to meet stricter safety standards and performance expectations. In addition, environmental and regulatory pressures are pushing the market toward sustainable solutions. Many medical device companies are seeking alternatives to PVC due to concerns over plasticizers and environmental impact. This is prompting innovation in biodegradable or recyclable tubing options, though these alternatives are still under development and not yet widely adopted. A few more trends are worth highlighting: ✅  Customization and precision: Manufacturers are focusing on producing highly customized tubing to meet specific client needs, including multi-lumen and co-extruded designs. ✅  Automation and digital control: Advances in extrusion equipment, including real-time monitoring and control systems, are improving quality and efficiency. ✅  Global expansion: Emerging markets in Asia-Pacific and Latin America are witnessing increased investment in healthcare infrastructure, boosting demand for medical tubing. Overall, the extrusion medical tubing market is evolving with changing medical practices, material advancements, and regulatory shifts. Staying informed about these trends is essential for manufacturers, suppliers, and healthcare professionals aiming to remain competitive and compliant in a fast-changing environment. At Demax, we have a deep understanding of the precision and quality required in manufacturing medical tubing. We combine advanced materials, proprietary extrusion techniques, and stringent quality controls to develop tubing solutions that meet the evolving needs of OEM and ODM partners globally. Unlike OEM providers, we offer full-cycle ODM services – from concept development and prototyping to final product manufacturing and regulatory support. ✔ Precision control of lumen size and wall thickness ✔ Multi-layer and multi-lumen tubing capabilities ✔ Compatibility with a range of biocompatible materials ✔ Custom formulations and coatings for specific use cases With our in-house R&D, we are continually improving the performance and safety of our tubing solutions to meet the changing demands of medical professionals and patients. Innovations Reshaping the Extrusion Medical Tubing Market Advancements in materials and manufacturing